AIF1 — Allograft inflammatory factor 1
AIF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AIF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1, ENC1 +21 more | View in SCUBA |
| CD8⁺ T cells | Naive/Central Memory T cell maturation | ATM, CCR7, FCMR, FOXP1, KLF2, KLF3, LDLRAP1, LEF1 +7 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, DPYD, FAM117B +7 more | |
| Macrophages | MHC-II Antigen Presentation Innate immunity | B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3, CTSC +19 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Activation Innate immunity | ALOX5AP, C4orf3, CD14, MCEMP1, PRELID1, SLC2A3, TIMP1, TYMP +1 more |
About the gene
| Synonyms | AIF-1, Em:AF129756.17, IBA1, IRT-1 |
|---|---|
| Chromosome | 6: 31615217-31617021 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.