CLEC7A — C-type lectin domain containing 7A
CLEC7A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLEC7A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CDKN2A, INPP1, MAP3K5, N4BP1, PBXIP1 +8 more | View in SCUBA |
| Endothelial | Macrophage Contamination Cell contamination | CCDC68, CORO2A, CPVL, DIXDC1, DOCK11, LPCAT4, PTGS1, ST8SIA4 +3 more | View in SCUBA |
| Macrophages | Antiviral ISG Response Antiviral | ADAR, APOL6, ARID5A, DDX60, DTX3L, EIF2AK2, ERICH1, IFIH1 +29 more | View in SCUBA |
| Monocytes | Complement Receptor Activation Lysosomal & pahgocytosis | AVPI1, C5AR1, C5AR2, CSF2RA, MAT2A, METRNL, PTPRE, RAB20 +1 more | View in SCUBA |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CSF2RB, CSF3R, CYTH4, FCGR2A, LY96, SLC11A1, SLC25A37 +1 more |
About the gene
| Synonyms | CD369, CLECSF12, DECTIN-1, hDectin-1, SCARE2 |
|---|---|
| Chromosome | 12: 10116777-10130258 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.