Macrophage Contamination
Gene co-expression module in Endothelial
| Category | Cell contamination |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub genes are strongly myeloid/macrophage markers: CPVL (carboxypeptidase expressed in macrophages), CLEC7A (Dectin-1, canonical macrophage/dendritic cell pattern recognition receptor), DOCK11 (Rho GEF active in macrophage/immune cell migration), TAGAP (T-cell activation GTPase-activating protein), CORO2A (coronin actin regulator in immune cells), PTGS1 (COX-1, constitutively expressed in macrophages). CCDC68 and TESC are less specific. The overall signature is consistent with macrophage contamination in the endothelial cell dataset. Low mean expression (0.119) and low pct positive (11.1%) are consistent with rare contaminating cells.
Genes
CCDC68, CLEC7A, CORO2A, CPVL, DIXDC1, DOCK11, LPCAT4, PTGS1, ST8SIA4, TAGAP, TCEA3, TESC
Most correlated modules
- Venular Inflammatory Activation · correlation 0.92
- Venous EC Identity · correlation 0.92
- Quiescent EC Identity · correlation 0.89
- IL33 Alarmin Signaling · correlation 0.85
- Arterial EC Identity · correlation 0.85
- Quiescent Arterial EC · correlation 0.76
- Hypoxia Stress Response · correlation 0.70
- Angiogenic Metabolic Adaptation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.