ST8SIA4 — ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
ST8SIA4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ST8SIA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B Cell Identity Signaling B cell maturation | ARID4B, ELF1, LYN, PAX5, RHOH, TMEM131, UGCG | View in SCUBA |
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
| Endothelial | Macrophage Contamination Cell contamination | CCDC68, CLEC7A, CORO2A, CPVL, DIXDC1, DOCK11, LPCAT4, PTGS1 +3 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, IL7, ITIH5, KCNS3, KITLG, LIFR +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10 +23 more | |
| Macrophages | Myeloid Receptor Signaling Innate immunity | ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15 +29 more | View in SCUBA |
About the gene
| Synonyms | PST, PST1, SIAT8D |
|---|---|
| Chromosome | 5: 100806933-100903282 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted secreted proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8- linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.