Antiviral ISG Response
Gene co-expression module in Macrophages
| Category | Antiviral |
|---|---|
| Genes | 38 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 17 of 38 genes have a known function matching the annotation |
Why this annotation
This module contains a second tier of interferon-stimulated genes and innate antiviral sensors: STAT2 (ISG transcription factor), EIF2AK2 (PKR, dsRNA sensor), IFIH1 (MDA5, cytosolic RNA sensor), DDX60 (RNA helicase antiviral), SAMD9/SAMD9L (antiviral restriction factors), SP110 (nuclear body antiviral), PML (promyelocytic leukemia, antiviral nuclear body), PARP9/PARP14/PARP10 (mono-ADP-ribosylation antiviral), DTX3L (ISG E3 ligase), XAF1 (XIAP antagonist, ISG), IFIT5, PLSCR1, RNF213, PNPT1. This is a neighbor to M2 (canonical ISGs) and represents the broader interferon/antiviral transcriptional program including sensors and effectors. Together M2 and M120 form a comprehensive type I IFN response.
Genes
ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1, IFIH1, IFIT5, MLKL, MOV10, MYD88, NAPA, NECTIN2, NT5C3A, PARP10, PARP12, PARP14, PARP9, PHF11, PLSCR1, PML, PNPT1, PTPRC, RNF213, RRBP1, SAMD9, SAMD9L, SHFL, SP110, ST3GAL5, STAT2, TFEC, TOR1B, TRIM22, UBE2J1, XAF1
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.