DOCK11 — Dedicator of cytokinesis 11
DOCK11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Macrophage Contamination Cell contamination | CCDC68, CLEC7A, CORO2A, CPVL, DIXDC1, LPCAT4, PTGS1, ST8SIA4 +3 more | View in SCUBA |
| Gamma-delta T cells | mTOR-Exocyst Signaling TCR Signaling | ANKRD36C, ARFGEF1, CGGBP1, CTC1, EXOC1, EXOC4, FRYL, GSK3B +12 more | |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, ARHGEF7, DIP2B, DNAAF9, EVI5, GNAQ, IL1RAP +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK2, ERBIN, FRYL +8 more |
About the gene
| Synonyms | ACG, FLJ32122, FLJ43653, ZIZ2 |
|---|---|
| Chromosome | X: 118495815-118686163 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.