SCUBA

PFKFB3 — 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

PFKFB3 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PFKFB3's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsEffector activation NFkB
TCR/AP1/NFKb pathway
ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 moreView in SCUBA
FibroblastsHypoxia Metabolic Stress
Stress
ABL2, DYRK3, EMP1, ERRFI1, HMOX1, NFATC1, PIM1, SERPINE1 +3 moreView in SCUBA
Gamma-delta T cellsChromatin Epigenetic Regulation
DNA/chromatin regulation
ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more
Glial cellsIntegrated Stress Response
Stress
ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MCL1 +3 moreView in SCUBA
Innate lymphoid cellsNK ILC Tissue Homing
Homing & TEM
ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 moreView in SCUBA
Lymphatic endothelialChromatin Remodeling
DNA/chromatin regulation
ASXL1, CHD1, GATAD2A, KMT2E, LONRF3, MED13, NUP153, RYBP +1 moreView in SCUBA
MacrophagesNF-κB Inflammatory Activation
Inflammatory
CYRIA, GPR132, HIVEP1, KMO, NFATC1, NFKB1, PDE4B, USP36View in SCUBA
Mucosal-associated invariant T cellT cell Quiescence
T cell maturation
AGO2, AUTS2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1 +13 more
Natural Killer cellsGlucocorticoid Response
Immune regulation
AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1 +11 moreView in SCUBA
NeutrophilsC5aR Complement Activation
Innate immunity
ADGRG3, C5AR1, CD55, ITPRIP, LAPTM5, MCL1, PTPRE, RYBP +3 more

About the gene

Chromosome10: 6144934-6254644
Predicted locationIntracellular
Essential geneNo
Protein classEnzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionHydrolase, Kinase, Multifunctional enzyme, Transferase

Function

Catalyzes both the synthesis and degradation of fructose 2,6- bisphosphate.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.