NF-κB Inflammatory Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub genes are NFKB1 (master NF-κB transcription factor), PDE4B (cAMP phosphodiesterase regulating inflammatory signaling), NFATC1 (calcium-dependent transcription factor in immune activation), HIVEP1 (NF-κB-related enhancer binding protein), GPR132 (inflammatory lipid-sensing GPCR), KMO (kynurenine monooxygenase, tryptophan catabolism/immunomodulation), PFKFB3 (glycolytic enzyme upregulated in inflammatory macrophage metabolic reprogramming), CYRIA (Rac1 GEF activator). This is a coherent NF-κB-centered inflammatory activation module with associated metabolic reprogramming (PFKFB3, KMO) characteristic of classically activated macrophages. Enriched in mono_mac.
Genes
CYRIA, GPR132, HIVEP1, KMO, NFATC1, NFKB1, PDE4B, PFKFB3, USP36
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.95
- Innate Immune Dampening · correlation 0.93
- Autophagy Vesicle Trafficking · correlation 0.93
- Epigenetic Remodeling · correlation 0.92
- ER Stress Response · correlation 0.90
- PI3K Lipid Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.