USP36 — Ubiquitin specific peptidase 36
USP36 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
USP36's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immediate early response BCR/AP1/NFKb pathway | CCNT1, CREM, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4 +7 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more | View in SCUBA |
| Gamma-delta T cells | IFN-gamma Receptor Signaling Inflammation | BORCS5, CCDC93, CDC42SE2, DHCR7, EML4, IFNGR1, PDE4B, PGRMC2 +3 more | |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | CYRIA, GPR132, HIVEP1, KMO, NFATC1, NFKB1, PDE4B, PFKFB3 | View in SCUBA |
| Mucosal-associated invariant T cell | cAMP Immune Regulation Immune regulation | CREM, FAM177A1, JMJD6, MAPKAPK2, METRNL, PDE4B, SNX9, SYAP1 |
About the gene
| Synonyms | FLJ12851, KIAA1453 |
|---|---|
| Chromosome | 17: 78787381-78841441 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, RNA-binding, Thiol protease, Transferase |
| Biological process | Ubl conjugation pathway |
Function
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins. Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability. Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing. Binds to pre-rRNAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.