NFATC1 — Nuclear factor of activated T cells 1

NFATC1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFATC1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	NFAT activation TCR/AP1/NFKb pathway	AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more	View in SCUBA
Endothelial	Inflammatory Angiogenesis Endothelial cell development	FAM241A, FAM43A, KLF6, MYC, PHLDA1, PIM3, PLEKHO2, RALGDS +7 more	View in SCUBA
Fibroblasts	Hypoxia Metabolic Stress Stress	ABL2, DYRK3, EMP1, ERRFI1, HMOX1, PFKFB3, PIM1, SERPINE1 +3 more	View in SCUBA
Innate lymphoid cells	Transcriptional Regulation DNA regulation & transcription	ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more	View in SCUBA
Macrophages	NF-κB Inflammatory Activation Inflammatory	CYRIA, GPR132, HIVEP1, KMO, NFKB1, PDE4B, PFKFB3, USP36	View in SCUBA

About the gene

Synonyms	NF-ATC, NFAT2, NFATc
Chromosome	18: 79395856-79529325
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.