DDA1 — DET1 and DDB1 associated 1
DDA1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DCTN2, EIF4E2, FKBP3, GID8 +17 more | View in SCUBA |
About the gene
| Synonyms | C19orf58, MGC2594, PCIA1 |
|---|---|
| Chromosome | 19: 17309518-17323298 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Functions as a component of numerous distinct DCX (DDB1-CUL4- X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.