Mitochondrial Translation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial ribosomal proteins (MRPL28, MRPL13, MRPS12), cytosolic ribosome-related (RPL26L1, PFDN6), proteasome (PSMD1), and OxPhos components (NDUFB6, CISD3). This is a housekeeping/biogenesis signature reflecting metabolic and translational machinery, with strong mitochondrial ribosome representation. Uniform low expression across subsets. Neighbor modules (M86, M85) are activation/Treg programs, but this module is functionally distinct, likely reflecting shared upregulation of metabolic machinery upon activation/inflammation (positive delta_inflammation). The mix of mitoribosomes and OxPhos leans Mitochondrial.
Genes
ARF5, CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3, GID8, ITPA, JOSD2, MRPL13, MRPL28, MRPS12, NDUFB6, NUTF2, PFDN6, PITPNA, PITPNM1, PSMD1, PWP1, RPL26L1, TMEM179B, TSN, YIF1A, ZDHHC12
Most correlated modules
- Lipid Metabolism · correlation 0.96
- CD4 Lineage Identity · correlation 0.94
- Vesicle Trafficking Signaling · correlation 0.92
- OxPhos & proteasome · correlation 0.88
- Leukocyte Motility · correlation 0.88
- Immune Regulation · correlation 0.86
- Oxidative Phosphorylation · correlation 0.85
- mRNA Processing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.