DCTN2 — Dynactin subunit 2
DCTN2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCTN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DDA1, EIF4E2, FKBP3, GID8 +17 more | View in SCUBA |
| Gamma-delta T cells | Complex I Assembly Mitochondrial & OxPhos | AKR7A2, AP2S1, BLOC1S1, HSD17B10, LAMTOR2, MGMT, MRPL34, MRPL51 +13 more | |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK, KDELR1 +11 more | View in SCUBA |
About the gene
| Synonyms | DCTN-50, RBP50 |
|---|---|
| Chromosome | 12: 57529633-57547224 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.