ER Protein Translocation
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 31 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes SEC62 (ER protein translocation channel), EMC3 (ER membrane protein complex subunit 3), TMED9 (p24 family/COPI vesicle cargo receptor), LMAN2 (lectin mannose-binding/ER-Golgi), SRPRA (signal recognition particle receptor alpha/ER targeting), SLC3A2 (4F2hc/amino acid transporter heavy chain), SPNS1 (lysosomal transporter), DDRGK1 (UFMylation/ER stress response), ACADVL (very long chain acyl-CoA dehydrogenase/mitochondrial FAO), ARRB2 (beta-arrestin 2/receptor internalization), SLC39A7 (ZIP7/ER zinc transporter). The dominant program is ER protein translocation and ER-Golgi trafficking. SEC62, EMC3, SRPRA, LMAN2, TMED9 all function in ER protein import/processing. Mild mono_mac enrichment for SEC62, SPNS1, SAT2, SLC3A2. Neighbor M97 also contains EMC6 (ER membrane complex), reinforcing the ER processing theme.
Genes
ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3, ELOVL1, EMC3, LMAN2, MBOAT7, MED10, MED28, MGAT4B, MTCH1, OSER1, PEF1, PLEKHJ1, PNKP, PPP4C, SAT2, SDF2, SEC62, SLC39A7, SLC3A2, SPNS1, SRPRA, TBL2, TMED9, TMEM179B
Most correlated modules
- ERAD Proteasome · correlation 0.94
- Protein Biogenesis · correlation 0.94
- Low-Coherence Mixed · correlation 0.93
- Transcriptional Elongation · correlation 0.93
- Mixed Housekeeping · correlation 0.92
- RAS-MAPK Signaling · correlation 0.91
- Proteasome UPS · correlation 0.91
- Lipid-Sensing Transcriptional · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.