DEFB1 — Defensin beta 1
DEFB1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEFB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Type I Interferon Antiviral | CMPK2, HERC5, IFIT1, IFIT2, IFIT3, OASL, OPTN, RSAD2 +1 more | View in SCUBA |
About the gene
| Synonyms | BD1, DEFB-1, DEFB101, HBD-1, HBD1, MGC51822 |
|---|---|
| Chromosome | 8: 6870592-6877936 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins, Transporters |
| Molecular function | Antibiotic, Antimicrobial, Defensin |
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.