HERC5 — HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HERC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2 +23 more | View in SCUBA |
| CD8⁺ T cells | Antiviral ISG Response Inflammation | CMPK2, HELZ2, IFIT1, IFIT3, ISG20, MX2, NT5C3A, PPM1K +1 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | AKAP7, ARID1A, CEP57, EIF4E, ENOSF1, GGNBP2, HNRNPD, KTN1 +8 more | |
| Monocytes | Type I Interferon Antiviral | CMPK2, DEFB1, IFIT1, IFIT2, IFIT3, OASL, OPTN, RSAD2 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, IFI16 +18 more |
About the gene
| Synonyms | CEB1 |
|---|---|
| Chromosome | 4: 88457119-88506163 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway |
Function
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance. Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation. (Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.