RSAD2 — Radical S-adenosyl methionine domain containing 2
RSAD2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RSAD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Effector ISG Anti-viral | GOLGA7B, KIF5C, KIT, MAP2K6, MVB12B, NMUR1, PLCG1, PLOD3 +8 more | View in SCUBA |
| CD8⁺ T cells | Antiviral ISG Response Inflammation | CMPK2, HELZ2, HERC5, IFIT1, IFIT3, ISG20, MX2, NT5C3A +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Antiviral | CMPK2, DEFB1, HERC5, IFIT1, IFIT2, IFIT3, OASL, OPTN +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HELZ2, HERC6, IFIT1, LAMP3, LGALS9, MX2, OAS3 +2 more |
About the gene
| Synonyms | cig5, vig1, Viperin |
|---|---|
| Chromosome | 2: 6865557-6898239 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Function
Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM- dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)- mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.