IFIT1 — Interferon induced protein with tetratricopeptide repeats 1
IFIT1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IFIT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Antiviral ISG Response Inflammation | CMPK2, HELZ2, HERC5, IFIT3, ISG20, MX2, NT5C3A, PPM1K +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT2, IFIT3, IFIT5 +9 more | View in SCUBA |
| Lymphatic endothelial | Type I Interferon Inflammation | BST2, CD74, CLEC14A, HLA-DRA, HLA-DRB1, IFI6, IFIT2, IFIT3 +4 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT2 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Antiviral | CMPK2, DEFB1, HERC5, IFIT2, IFIT3, OASL, OPTN, RSAD2 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HELZ2, HERC6, LAMP3, LGALS9, MX2, OAS3, PLSCR1 +2 more |
About the gene
| Synonyms | G10P1, GARG-16, IFI56, IFNAI1 |
|---|---|
| Chromosome | 10: 89392546-89406487 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Function
Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.