OASL — 2'-5'-oligoadenylate synthetase like
OASL belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OASL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Type I Interferon Inflammation | BST2, CHMP5, EIF2AK2, LAP3, NAPA, NMI, PLSCR1, SPATS2L +1 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15 +6 more | View in SCUBA |
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | AXIN1, B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, GTF3C1 +10 more | |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Antiviral | CMPK2, DEFB1, HERC5, IFIT1, IFIT2, IFIT3, OPTN, RSAD2 +1 more | View in SCUBA |
About the gene
| Synonyms | OASL1, p59OASL, TRIP14 |
|---|---|
| Chromosome | 12: 121017763-121039246 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.