OPTN — Optineurin
OPTN belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OPTN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | IFN-gamma Response Inflammation | CASP3, GBP5, IFI16, IRF2, SP100, SP140, TNFSF10, WIPF1 | View in SCUBA |
| Endothelial | Complement Innate Immune Inflammation | C1R, C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD +9 more | View in SCUBA |
| Hematopoietic progenitor cells | T-cell Progenitor Lymphcyte development | DSC2, GATA3, HOXB5, LAG3, MDK, PTMS, SELENOP, SKAP1 +2 more | |
| Lymphatic endothelial | Apoptosis Immune Regulation Immune regulation | A4GALT, CFLAR, COX17, GRINA, MPZL1, NINJ1, PAWR, RCN1 +2 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Monocytes | Type I Interferon Antiviral | CMPK2, DEFB1, HERC5, IFIT1, IFIT2, IFIT3, OASL, RSAD2 +1 more | View in SCUBA |
About the gene
| Synonyms | FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP |
|---|---|
| Chromosome | 10: 13099449-13138308 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Autophagy, Host-virus interaction, Immunity, Innate immunity |
Function
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin- coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response. During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.