IFIT3 — Interferon induced protein with tetratricopeptide repeats 3
IFIT3 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IFIT3's module in each cell type
About the gene
| Synonyms | CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, RIG-G |
|---|---|
| Chromosome | 10: 89327307-89377473 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.