FMO3 — Flavin containing dimethylaniline monoxygenase 3
FMO3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FMO3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FHL2, FN1, PDLIM3, RARRES2, TGFBI, TNC +1 more | View in SCUBA |
About the gene
| Synonyms | FMOII |
|---|---|
| Chromosome | 1: 171090901-171117819 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Monooxygenase, Oxidoreductase |
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.