Inflammatory ECM Remodeling
Gene co-expression module in Pericytes
| Category | ECM remodeling |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
VCAM1 (vascular cell adhesion molecule, inflammatory marker), TNC (tenascin-C, ECM remodeling in inflammation), FN1 (fibronectin), TGFBI (TGF-beta-induced ECM glycoprotein), CCDC80 (stromal ECM), FHL2 (focal adhesion LIM protein), CD44 (inflammatory cell adhesion receptor), and RARRES2 (chemerin, inflammatory adipokine) collectively define an inflammatory ECM remodeling program. The largest delta_inflammation scores in this batch (~1.2) and strong remission reversal support an inflammation-driven ECM remodeling state.
Genes
CCDC80, CD44, FHL2, FMO3, FN1, PDLIM3, RARRES2, TGFBI, TNC, VCAM1
Most correlated modules
- Complement Regulatory Pericyte · correlation 0.81
- Pericyte ECM Production · correlation 0.81
- Inflammatory Pericyte Activation · correlation 0.77
- Fibrillar Collagen Production · correlation 0.74
- Pericyte Inflammatory Activation · correlation 0.73
- Smooth Muscle Contractile · correlation 0.66
- Pericyte Identity Signaling · correlation 0.66
- Quiescent Pericyte State · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.