RARRES2 — Retinoic acid receptor responder 2
RARRES2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RARRES2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Metallothionein Stress Response Stress | CADM3, CLU, CTNNAL1, IFI35, MT1E, MT1M, MT2A, SERPINA5 +1 more | View in SCUBA |
| Goblet cells | Anti-inflammatory Lipid Signaling Housekeeping | AQP1, CDCA7, FBL, IMPDH2, PRDX5, PTGDR, UGT2A3 | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FHL2, FMO3, FN1, PDLIM3, TGFBI, TNC +1 more | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PCSK1N +6 more | View in SCUBA |
About the gene
| Synonyms | HP10433, TIG2 |
|---|---|
| Chromosome | 7: 150338317-150341662 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Biological process | Chemotaxis, Differentiation, Inflammatory response |
Function
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti- inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.