TNC — Tenascin C
TNC belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heparan Sulfate Remodeling ECM remodeling | ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, JMJD1C +11 more | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FHL2, FMO3, FN1, PDLIM3, RARRES2, TGFBI +1 more | View in SCUBA |
About the gene
| Synonyms | DFNA56, HXB, MGC167029, TN |
|---|---|
| Chromosome | 9: 115019575-115118207 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.