PDLIM3 — PDZ and LIM domain 3
PDLIM3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDLIM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia Stress Response Stress | ABCA5, ALDH2, BAALC, CIRBP, EGLN3, EPB41, FARP1, FTL +7 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Migration & adhesion | CAVIN1, FNBP1, KLHL5, LDLRAD3, MAP3K20, PHLDB2, PLEKHO1, PLP2 +6 more | View in SCUBA |
| Glial cells | COX-2/NF-κB Inflammation Inflammation | ABL2, ARID5A, BCL3, EMP1, LMNA, PHLDA1, PTGS2 | View in SCUBA |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PON2 +9 more | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FHL2, FMO3, FN1, RARRES2, TGFBI, TNC +1 more | View in SCUBA |
About the gene
| Synonyms | ALP |
|---|---|
| Chromosome | 4: 185500660-185535507 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
May play a role in the organization of actin filament arrays within muscle cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.