FPR3 — Formyl peptide receptor 3
FPR3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FPR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte Tissue Infiltration Migration & adhesion | CD59, CDCP1, NRP1, NRP2, PDE4DIP, PLAU, PMP22, PTMS +3 more | View in SCUBA |
About the gene
| Synonyms | FMLPY, FPRH1, FPRL2, RMLP-R-I |
|---|---|
| Chromosome | 19: 51795157-51826190 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Chemotaxis |
Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.