PMP22 — Peripheral myelin protein 22

PMP22 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PMP22's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Inflammatory EC Activation ECM remodeling	C4orf48, CAPG, CD200, COL6A1, COL6A2, IGFBP5, LAMP3, NT5E +4 more	View in SCUBA
Fibroblasts	Homeostatic Fibroblast Identity ECM production	ADGRL2, C1S, DCN, DKK3, DPYSL2, IL34, IL6ST, LUM +6 more	View in SCUBA
Glial cells	Glial Myelination Identity Myelination	AP1S2, CALM2, CD81, CD9, COMT, GPM6B, GSN, IGFBP7 +6 more	View in SCUBA
Goblet cells	Basement Membrane Remodeling migration & adhesion	AHNAK, CD55, CYP3A5, F3, GPRC5A, LAMA3, LAMB3, LAMC2 +7 more	View in SCUBA
Macrophages	ER Protein Processing Housekeeping	ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more	View in SCUBA
Monocytes	Monocyte Tissue Infiltration Migration & adhesion	CD59, CDCP1, FPR3, NRP1, NRP2, PDE4DIP, PLAU, PTMS +3 more	View in SCUBA
Pericytes	Pericyte ECM Production ECM production	AEBP1, CALD1, COL14A1, GUCY1B1, LURAP1L, SDC2, TPPP3, VCL	View in SCUBA
Smooth muscle cells	Matrisome Regulators ECM remodeling	ITM2C, LPP, LUM, NBL1, S100A13, TCEAL4, TIMP2, TMEM176B +1 more	View in SCUBA

About the gene

Synonyms	CMT1A, GAS3, HMSNIA, HNPP, Sp110
Chromosome	17: 15229773-15272292
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Function

Might be involved in growth regulation, and in myelinization in the peripheral nervous system

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.