NRP2 — Neuropilin 2
NRP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NRP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Cytoskeletal Scaffold Cytoskeletal | ADD3, ANTXR2, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, RECK +2 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ALPL, ARL4C, CD44, CHST15, CXCL6, DCBLD1, EVA1A, MAP3K5 +4 more | View in SCUBA |
| Glial cells | Peripheral Nerve Myelination Myelination | ABCA8, AKAP12, CIT, COL27A1, ITGB4, LGI4, SAMHD1, SYT10 | View in SCUBA |
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | ARFIP1, BCL2L1, CDS2, CLPB, EHD4, GNB4, HAVCR2, IVNS1ABP +9 more | View in SCUBA |
| Monocytes | Monocyte Tissue Infiltration Migration & adhesion | CD59, CDCP1, FPR3, NRP1, PDE4DIP, PLAU, PMP22, PTMS +3 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1 +12 more | View in SCUBA |
About the gene
| Synonyms | VEGF165R2 |
|---|---|
| Chromosome | 2: 205681990-205798133 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Developmental protein, Heparin-binding, Receptor |
| Biological process | Differentiation, Host-virus interaction, Neurogenesis |
Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.