PDE4DIP — Phosphodiesterase 4D interacting protein

PDE4DIP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PDE4DIP's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Integrin adhesion migration & adhesion	ATP11B, CD84, CEP85L, CYTH1, HTRA1, ITGAL, MYO7A, PCNX2 +4 more	View in SCUBA
Innate lymphoid cells	ILC Identity Program Differentiation	AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more	View in SCUBA
Macrophages	Osmotic Stress Response Stress	ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more	View in SCUBA
Monocytes	Monocyte Tissue Infiltration Migration & adhesion	CD59, CDCP1, FPR3, NRP1, NRP2, PLAU, PMP22, PTMS +3 more	View in SCUBA

About the gene

Synonyms	CMYA2, KIAA0454, KIAA0477, MMGL
Chromosome	1: 148808140-149048286
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Disease related genes, Essential proteins, Predicted intracellular proteins

Function

Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes (By similarity). Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.