GALNT12 — Polypeptide N-acetylgalactosaminyltransferase 12
GALNT12 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GALNT12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ARFGEF3, B4GALT4, CANT1, ERGIC1, OS9, ROCK2, UAP1, USO1 +1 more | View in SCUBA |
About the gene
| Synonyms | GalNAc-T12 |
|---|---|
| Chromosome | 9: 98807670-98850081 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.