UAP1 — UDP-N-acetylglucosamine pyrophosphorylase 1
UAP1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ARFGEF3, B4GALT4, CANT1, ERGIC1, GALNT12, OS9, ROCK2, USO1 +1 more | View in SCUBA |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | ADIPOR1, BIRC3, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLF11 +10 more | |
| Natural Killer cells | Circadian Innate Signaling Inflammation | ARRDC2, CRY1, ITPRIP, MGAT4A, NOCT, PTPRE, SLC15A4, TRAPPC10 +1 more | View in SCUBA |
About the gene
| Synonyms | AgX, AGX1, SPAG2 |
|---|---|
| Chromosome | 1: 162561722-162601240 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Nucleotidyltransferase, Transferase |
| Biological process | Immunity, Innate immunity |
Function
Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.