Mucin O-Glycosylation
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
GALNT12 (initiates O-GalNAc glycosylation of mucins), B4GALT4 (elongates O-glycan chains), UAP1 (synthesizes UDP-GlcNAc, substrate for O-glycosylation), CANT1 (Golgi UDPase, recycles nucleotide sugars), ERGIC1 and YIPF5 (ER-Golgi intermediate compartment), USO1 (ER-to-Golgi tethering factor), ARFGEF3 (ARF GEF at Golgi), OS9 (ERAD lectin), ROCK2 (Rho kinase, may regulate Golgi structure). The glycosyltransferases and nucleotide sugar metabolism genes are directly relevant to mucin O-glycosylation. Upregulated in UC and CD inflammation. Neighbor to M38 (ERAD/glycan precursors) and M40 (secretory regulation).
Genes
ARFGEF3, B4GALT4, CANT1, ERGIC1, GALNT12, OS9, ROCK2, UAP1, USO1, YIPF5
Most correlated modules
- N-Glycosylation ER Stress · correlation 0.90
- ER Protein Translocation · correlation 0.89
- Protein trafficking & glycosylation · correlation 0.87
- Goblet Secretory Identity · correlation 0.85
- Mucin Folding Machinery · correlation 0.84
- ERAD ER Homeostasis · correlation 0.84
- ER Targeting ERAD · correlation 0.83
- UPR Chaperone Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.