ABCA5 — ATP binding cassette subfamily A member 5
ABCA5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia Stress Response Stress | ALDH2, BAALC, CIRBP, EGLN3, EPB41, FARP1, FTL, LRP5 +7 more | View in SCUBA |
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ABCA10, ADCY9, EXOC6B, GABRA2, IL6R, INSR, MAGI1, MBNL1 +6 more | View in SCUBA |
| Innate lymphoid cells | NK/ILC1 Identity Differentiation | ARHGAP15, CD37, CD96, CD99, CTSD, EPC1, GIMAP2, GIMAP6 +17 more | View in SCUBA |
About the gene
| Synonyms | EST90625 |
|---|---|
| Chromosome | 17: 69244311-69327244 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.