Inflammatory Colonocyte State
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module with mixed subset enrichment. REG4 (21.2x inf_colono), ALDOB (7.7x), MUC2 (8.5x), TM4SF20 (6.3x) point to an inflammatory/regenerative colonocyte state, but these genes have weak-to-moderate membership. Core hub genes VPS13A, SYTL2, GALNT12 suggest vesicle trafficking and glycosylation. DNAH7, CYBRD1, TM6SF2 are enriched in sen_colono. As a neighbor of M48 (mature colonocyte metabolism), this module likely captures a transitional colonocyte state with vesicle/lipid trafficking activity, partially overlapping with inflammatory and senescent colonocyte programs. The mixed membership and moderate coherence indicate two sub-programs are combined.
Genes
Most correlated modules
- Brush Border Cytoskeleton · correlation 0.69
- Membrane Cytoskeletal Remodeling · correlation 0.69
- Colonocyte Water Transport · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.