USO1 — USO1 vesicle transport factor
USO1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
USO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | CASP8AP2, CNPPD1, CUL4A, CYBC1, EPRS1, FAM8A1, GTF2H3, IL17RA +15 more | |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ARFGEF3, B4GALT4, CANT1, ERGIC1, GALNT12, OS9, ROCK2, UAP1 +1 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Epigenetic Maintenance DNA/chromatin regulation | ATAD2B, ATXN10, DENND6A, DGLUCY, DMTF1, FYCO1, GALK2, HDLBP +13 more |
About the gene
| Synonyms | p115, TAP, VDP |
|---|---|
| Chromosome | 4: 75724577-75814286 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.