PCSK5 — Proprotein convertase subtilisin/kexin type 5
PCSK5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCSK5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7 +15 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | AFAP1L2, BMP4, CFAP36, FUT8, ITPR2, JAG1, LTBP4, NEBL +6 more | View in SCUBA |
About the gene
| Synonyms | PC5, PC6, SPC6 |
|---|---|
| Chromosome | 9: 75890644-76362975 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Pregnancy |
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.