GAPT — GRB2 binding adaptor protein, transmembrane
GAPT belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GAPT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation signaling B cell maturation | ANKRD44, BLK, BTN3A2, EVI2B, GPSM3, LBH, LTB, LY86 +9 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, LYST, MAP3K1, MNDA, POU2F2, RGS18, SLC24A4, TMEM154 +4 more | View in SCUBA |
About the gene
| Synonyms | C5orf29, FLJ33641 |
|---|---|
| Chromosome | 5: 58491435-58497090 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | B-cell activation |
Function
Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.