LY86 — Lymphocyte antigen 86
LY86 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LY86's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation signaling B cell maturation | ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LTB +9 more | View in SCUBA |
| Hematopoietic progenitor cells | Dendritic Cell Progenitor Myeloid development | BLNK, CCDC50, CD180, CLEC4A, HDAC9, HERPUD1, IRF8, NCF1 +1 more | |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
About the gene
| Synonyms | dJ80N2.1, MD-1 |
|---|---|
| Chromosome | 6: 6588108-6654983 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.