B cell activation signaling
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
This module is dominated by hematopoietic/lymphocyte signaling and B-lineage genes: BLK (B-lymphoid tyrosine kinase), LTB (lymphotoxin beta), LY86 (MD-1, B cell surface), GAPT (Grb2-binding adaptor expressed in B cells), RASGRP2, S1PR4, GPSM3, EVI2B, RIPOR2. This is a coherent immune/B-cell signaling and lymphocyte activation program. LTB, BLK, LY86, GAPT, RASGRP2 are strongly tied to B-cell maturation/activation and lymphoid organogenesis. Uniform expression consistent with intrinsic B cell state.
Genes
ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LTB, LY86, MTSS1, PPP3CA, RASGRP2, RIPOR2, S1PR4, SMIM14, SSR2, TLE1, TMEM154
Most correlated modules
- Membrane adhesion remodeling · correlation 0.78
- B-cell antigen presentation · correlation 0.74
- Interferon Response · correlation 0.73
- MHC-II antigen presentation · correlation 0.72
- Chromatin Regulation · correlation 0.71
- MHC-I Antigen Presentation · correlation 0.71
- Leukocyte Migration Signaling · correlation 0.70
- Lymphoid signaling regulators · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.