GDNF — Glial cell derived neurotrophic factor
GDNF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GDNF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-ID Stress Response Stress | BHLHE40, CCDC184, CFAP20, FOXC2, GADD45G, GDF15, HAS1, HCAR2 +9 more | View in SCUBA |
| Glial cells | BMP-SMAD Signaling Neroprotection | A2M, AQP1, ARC, CAPS, CRLF1, ID1, ID3, NRXN2 +3 more | View in SCUBA |
About the gene
| Synonyms | ATF1, ATF2, HFB1-GDNF |
|---|---|
| Chromosome | 5: 37812677-37840041 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor |
Function
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.