CFAP20 — Cilia and flagella associated protein 20
CFAP20 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFAP20's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cell cycle regulators DNA/chromatin regulation | CCDC28A, CCNDBP1, EAPP, IFNAR2, LAPTM4A, RBBP4, SH3GLB1 | View in SCUBA |
| Endothelial | Glucocorticoid Response Inflammation | CCM2L, DUSP6, INAFM2, INHBB, MIER2, MYLIP, NUAK1, OAZ2 +6 more | View in SCUBA |
| Fibroblasts | BMP-ID Stress Response Stress | BHLHE40, CCDC184, FOXC2, GADD45G, GDF15, GDNF, HAS1, HCAR2 +9 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CDKN1B, DDIT3, GIMAP5, HSPA5, KLF2, KLF4, ODC1, RHOB +2 more | View in SCUBA |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, B3GNT5, C2CD4B, FAM43A, INSIG1, LDLR, RALGDS, RND1 +2 more | View in SCUBA |
About the gene
| Synonyms | C16orf80, fSAP23, GTL3 |
|---|---|
| Chromosome | 16: 58113592-58129381 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.