BMP-ID Stress Response
Gene co-expression module in Fibroblasts
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
ID1 and ID3 (inhibitors of differentiation, downstream of BMP signaling) are top hub genes alongside GDF15 (growth differentiation factor 15, a stress-induced TGF-β superfamily member). BHLHE40 (basic helix-loop-helix transcription factor responsive to hypoxia and circadian signals), PMAIP1 (NOXA, pro-apoptotic BH3-only protein), ODC1 (ornithine decarboxylase, rate-limiting enzyme in polyamine synthesis), GADD45G (growth arrest and DNA damage response), HSPA6 (heat shock protein 70 family), and KLF6 (stress-responsive Krüppel-like factor) collectively define a cellular stress and BMP/ID signaling response. FOXC2 (lymphatic/mesenchymal transcription factor) and HAS1 (hyaluronan synthase) add stromal identity. The module is strongly restored in UC remission (delta_remission_UC = 0.703), suggesting it marks a homeostatic stress-adaptive fibroblast state suppressed during active inflammation.
Genes
BHLHE40, CCDC184, CFAP20, FOXC2, GADD45G, GDF15, GDNF, HAS1, HCAR2, HSPA6, ID1, ID3, ITPRIP, KLF6, MLF1, MT1A, ODC1, PMAIP1
Most correlated modules
- NF-κB Epigenetic Reprogramming · correlation 0.82
- Integrated Stress Response · correlation 0.68
- Inflammatory Fibroblast Activation · correlation 0.64
- Fibroblast Niche Identity · correlation 0.63
- Heat Shock Response · correlation 0.62
- Proteotoxic Stress Survival · correlation 0.60
- ECM Glycan Remodeling · correlation 0.59
- Retinoid Stromal Quiescence · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.