PIK3IP1 — Phosphoinositide-3-kinase interacting protein 1

PIK3IP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PIK3IP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Naive B cell B cell maturation	ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more	View in SCUBA
CD4⁺ T cells	Leukocyte adhesion signaling migration & adhesion	ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more	View in SCUBA
CD8⁺ T cells	TCR Complex Signaling TCR Signaling	ACAP1, ANXA1, CD37, CD3E, CITED2, DUSP1, EVL, LAPTM5 +4 more	View in SCUBA
Endothelial	Arterial EC Homeostasis Endothelial cell development	APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1 +10 more	View in SCUBA
Gamma-delta T cells	TCR Inhibitory Signaling Exhaustion	AFF4, CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20 +9 more
Innate lymphoid cells	Inflammasome Activation Inflammation	ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA +19 more	View in SCUBA
Mucosal-associated invariant T cell	MAIT Cell Identity T cell maturation	AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more
Natural Killer cells	Inflammatory Stress Response Stress	AKIRIN2, CCNH, CEBPD, CLASP1, FKBP5, H3C1, P2RX5, PARP8 +2 more	View in SCUBA

About the gene

Synonyms	HGFL, MGC17330, TrIP
Chromosome	22: 31281594-31292534
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Function

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.