P2RX5 — Purinergic receptor P2X 5
P2RX5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
P2RX5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B-cell identity B cell maturation | ALOX5AP, CD79B, HLA-DOB, IRF8, NCF1, PLEKHF2, SEC62, SIAH2 +7 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more | |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more | |
| Natural Killer cells | Inflammatory Stress Response Stress | AKIRIN2, CCNH, CEBPD, CLASP1, FKBP5, H3C1, PARP8, PIK3IP1 +2 more | View in SCUBA |
About the gene
| Synonyms | LRH-1, P2X5 |
|---|---|
| Chromosome | 17: 3672199-3696240 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Function
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride. May play a supporting role in the inflammatory response (By similarity). Non-functional
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.