HMGCR — 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCR belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMGCR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more |
About the gene
| Chromosome | 5: 75336329-75364001 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Oxidoreductase |
| Biological process | Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Function
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.