HMGCS1 — 3-hydroxy-3-methylglutaryl-CoA synthase 1
HMGCS1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMGCS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | ATF4 Stress Response Stress | ATF4, BRD2, CCNYL1, ERO1B, FUS, GLA, INSIG1, KLF10 +3 more | View in SCUBA |
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, ING1, KLF10 +12 more | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more | |
| Mucosal-associated invariant T cell | TCR-Induced Early Response TCR Signaling | ATF3, EGR1, GLA, IER3, NR4A1, NUP58, PPP1R15B, RHOB +3 more |
About the gene
| Synonyms | HMGCS |
|---|---|
| Chromosome | 5: 43287470-43313512 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.