ARHGEF12 — Rho guanine nucleotide exchange factor 12
ARHGEF12 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12, RAB10 +10 more | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES, HMGCR +12 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4, DERL1 +29 more | View in SCUBA |
| Macrophages | ER Stress Response Stress | ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1, ERO1B +14 more | View in SCUBA |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ASAP1, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, SERPINH1, TCEAL9 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0382, LARG |
|---|---|
| Chromosome | 11: 120336413-120489937 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.