Activation Stress Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
ATF3 is a stress-responsive transcription factor rapidly induced by inflammatory signals, TCR stimulation, and metabolic stress. RGS1 dampens GPCR signaling and is a marker of recently activated/tissue-conditioned T cells. HIC1 is a transcriptional repressor induced by stress/activation. HMGCS1 and LPIN1 reflect metabolic reprogramming toward lipid synthesis during activation. GPR18 is a lipid-sensing GPCR on lymphocytes. ARHGAP9, ARHGEF12, and NEDD9 regulate cytoskeletal dynamics during T cell activation and migration. SMURF2 modulates TGF-β signaling. SSH1 activates cofilin for actin remodeling. TNIP3 inhibits NF-κB. KIF13B mediates vesicle transport. The module represents an early activation/stress-response program with coupled metabolic and cytoskeletal reprogramming.
Genes
ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES, HMGCR, HMGCS1, KIF13B, LPIN1, METTL9, MEX3C, NEDD9, RGS1, SLC37A1, SMURF2, SSH1, TBC1D2B, TNIP3
Most correlated modules
- NK Receptor Expression · correlation 0.92
- mRNA Splicing Regulation · correlation 0.92
- T Cell Exhaustion · correlation 0.91
- Hypoxia Tissue Adaptation · correlation 0.90
- AHR/NF-κB Survival · correlation 0.89
- Chromatin Remodeling Signaling · correlation 0.89
- Gut-homing Residence · correlation 0.88
- Tissue Resident CD103+ · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.