IL2RA — Interleukin 2 receptor subunit alpha
IL2RA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL2RA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, DNPH1, GBP2, NAMPT, NDFIP2, NINJ2 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CD79B, CYGB, DNTT, EBF1, FRMD4A, IL7R +4 more | |
| Monocytes | IFN-γ Monocyte Response Inflammatory | ANKRD22, APOL3, ATF5, CXCL9, HAPLN3, IL2RG, LYSMD2, NFE2L3 +2 more | View in SCUBA |
About the gene
| Synonyms | CD25, IDDM10, IL2R |
|---|---|
| Chromosome | 10: 6010689-6062370 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.